Diagnostic laboratories are in a special position to identify and characterize inherited diseases of food animals. Many of these diseases are significant for the breed in which they occur, particularly if carriers are used for artificial insemination. Some of these diseases are potentially useful models of comparable human diseases.

Investigator: D O’Toole  

Publications

O'Toole D, Montgomery DL, Steadman L, O'Rourke B, Russell W, Dennis J: 2005, Status spongiosus of white matter in newborn Gelbvieh-cross calves.  J Vet Diagn Invest. 17(6):546-53.

Norrdin RW, Hoopes KJ, D. OToole D: 2004, Bone lesions of Salers with hemochromatosis. Vet Pathol 41(6):612-623.

Pruden SJ,  McAllister MM, Schultheiss PC, O'Toole, Christensen DE: 2004,  Abomasal emptying defect of sheep may be an acquired form of dysautonomia  Vet Pathol 2004 41: 164-169. 

O'Toole D, Kelly EJ, McAllister MM, et al: 2001, Hepatic failure and hemochromatosis of Salers and Salers-cross cattle. Vet Pathol. 2001 Jul;38(4):372-89.

O'Toole, D., Welch, V., Redland, K., Williams, E.S. (1993). Ubiquitinated inclusions in brains from Salers calves with B-mannosidosis. Vet Pathol 30(4):381-385.

O'Toole, D., Welch, V., Redland, K. (1993). Ubiquitin immunocytochemistry of spinal cord in hereditary porcine neuronal system degeneration. J Vet Diagn Invest 5(4):642-646.

O'Toole, D., Jeffrey, M., Jones, T., Morgan, G., Green, R. (1993). Pathology of renal dysplasia and bladder aplasia-hypoplasia in a flock of sheep. J Vet Diagn Invest 5(4):591-602.

O'Toole, D., Ingram, J., Welch, V., Bardsley, K., Haven, T., Nunamaker, C., Wells, G. (1994) An inherited lower motor neuron disease of pigs: clinical signs in two litters and pathology of an affected pig. J Vet Diagn Invest 6(1):62-71.

O'Toole, D., Wells, G.A.H., Ingram, J., Cooley, W.A., Hawkins, S.A.C. (1994). Ultrastructural pathology of an inherited lower motor neuron disease of pigs. J Vet Diagn Invest 6(2):230-237.