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University of Wyoming

UW Technologies Available for Licensing

 

Technology Disclosure: 06-116 Inositol-Based Chiral Phosphine Ligands

    Researchers at the University of Wyoming have developed an anologue of the Trost Ligand that enables enhanced regioselectivity in the metal-catalyzed allylic alkylation. The analogue uses either enantiomer of inositol rings rather than Trost’s cyclohexadiamines, thus resulting in increased regioselectivities.

A difficult aspect of the metal-catalyzed allylic alkylation is discrimination in unsymmetric substrates, which leads to mixtures of regioisomers (Tetrahedron Lett. 2005, 46, 353). The new ligand provides for increased selectivity (inositol ligand 24:1 vs Trost ligand 4:1 for example) while maintaining enantioselectivity inherent in the Trost system.

If you would like to learn more about this new diphosphine ligand, please contact the director of the University of Wyoming Research Products Center, Davona Douglass. We would be pleased to share further details.